Inherited ichthyosis and fungal infection: an update on pathogenesis and treatment strategies

Summary Inherited ichthyoses are a group of genodermatoses classified as either nonsyndromic or syndromic. Nonsyndromic and keratitis, ichthyosis deafness (KID) syndrome predispose to fungal infection. The diagnosis treatment infections underlying challenging. In this review, we summarize reported cases with infection over the past 50 years. Atypical manifestations such alopecia, papules brittle nails occurred in patients combined Various pathogenic mechanisms have been implicated, including mutations ichthyosis‐related genes leading disruption skin barrier via multiple pathways. Host immune disorders, atopy abnormal innate immunity also contribute susceptibility. Specific fungi may escape response. Extensive recurrent not uncommon ichthyosis, making cure more difficult increasing need for systemic antifungal therapy. Traditional new treatments aiming improve function could help prevent conclusion, close relationship between is vital importance clinical practice requires attention from physicians. More studies required investigate explore useful strategies.